A tour of the vast Vatican Museums is one of the top attractions in Rome. Depending upon your level of risk aversion, there are three ways to procure tickets to the Vatican Museums. The easiest is to deal with an American company with reliable customer service. We like Select Italy. Ordering your ticket in advance through a company like Select Italy is slightly more expensive than the other options. The advantages are that you are dealing with native English speakers, you can reserve a place during your travel planning at the date you require, and you won't have to stand in the long lines to buy a ticket (you may have to stand in a shorter one that spaces out the tours).
Select Italy offers a papal ticket to the Papal blessing.
You can also make reservations through the Online Ticket Office of the Vatican Museums.
A private guide for your Rome adventure can be a costly deal, but there are several advantages to hiring a private guide for your family vacation. For example, a small minivan is allowed to travel on the little streets that run through the heart of ancient Rome, where big tourist buses are forbidden, so a small, private tour with a guide can get you to more of the smaller places. Remember, a private guide will take you exactly where you want to go--you can skip the stuff you're not interested in.
Vatican Tours that take you to the Sistine Chapel for a peek at the frescoes are getting ever more crowded. If you've got a few extra bucks, The Roman Guy's "Privileged Entrance" Vatican Museums, Sistine Chapel & St. Peter's Basilica Tour will amaze and astound you. Remember to use the code WANDERING and get a 5% discount on this and other Roman Guy tours.
If you are planning a trip to Vatican City as a major part of your Rome experience, then you might want to stay in the area, as it can be considerably less expensive than staying in the center of Rome. You might check out Prati and Aurelio. The metro gets you anywhere else in tourist Rome you might want to go, so it's a good choice for staying in Rome that doesn't leave you without options.
And finally, did you know that you can Tour Rome in a Vintage Fiat 500?
Testaccio Restaurants - Eat like a real Roman!
Trastevere Guide - Everyone's favorite Rome Neighborhood.
Aventine Hill Guide - Find a really quite place to sleep in raucous Rome and have fantastic views of the historic center.
Rome Flaminio Guide - Get away to Rome's first "outskirt" and see the new MAXXI museum.